Time-dependent hazard rate of death in TT2 and TT3 protocols according to GEP-defined risk. (A) For TT2, the hazard rate of death declined steeply in high-risk myeloma to reach levels of low-risk disease at 5 to 6 years. (B) For TT3, the hazard rate of death declined steeply in high-risk myeloma to reach levels of low-risk disease at 4 to 5 years.