Frequency of patients with mutations where one or more of their mutations would influence the therapeutic decision. Overall, 43% of our patients with mutations had one or more of the SGI clinically relevant mutations. For patients without T315I, the difference in the frequencies among the disease phases was related to the higher incidence of mutations less sensitive to nilotinib in LBC/Ph⁺ ALL and AP. The frequency of patients with clinically relevant mutations to nilotinib (Y253H, E255K/V, and F359V/C) or to dasatinib (F317L) is calculated as the percentage of patients without an additional mutation that was less sensitive to both inhibitors.