Normalization of autoimmune phenotype of IL-2Rα⁻ mice by transgenic expression of Cyclon. (A) Spleens from 7-week-old IL-2Rα⁺, Cyclon-Tg IL-2Rα⁺, IL-2Rα⁻, and Cyclon-Tg IL-2Rα⁻ mice. (B) Cell numbers of splenocytes, CD4⁺, and CD8⁺ splenic T cells, and cells in inguinal lymph nodes from IL-2Rα⁺, Cyclon-Tg IL-2Rα⁺, IL-2Rα⁻, and Cyclon-Tg IL-2Rα⁻ mice. (C) Expression of CD44 on CD4⁺ and CD8⁺ splenic T cells from IL-2Rα⁺, Cyclon-Tg IL-2Rα⁺, IL-2Rα⁻, and Cyclon-Tg IL-2Rα⁻ mice. (D) Transgenic expression of Cyclon decreases IL-17 in serum of IL-2Rα⁻ mice. Serum concentrations of IL-17 were analyzed in 7-week-old IL-2Rα⁺, Cyclon Tg IL-2Rα⁺, IL-2Rα⁻, and Cyclon TgIL-2Rα⁻ mice by enzyme-linked immunosorbent assay.