PBMC phenotype before and after BMT in SCID patients. Mean numbers (± SEM) of CD20 B, CD3 T, and CD16 NK cells were obtained by flow cytometric analysis of SCID PBMCs studied before (A; N = 151) and at the latest time after transplantation (B; N = 120). Results from 2 patients with Artemis deficiency (1 surviving), 1 with CD45 deficiency, 4 with SCID of unknown molecular type (1 surviving), and from the 5 patients who received transplants elsewhere for whom we do not have the original pretransplantation data, are not included in Figures 1 and 2. Values for normal infant (A) and pediatric to young adult (B) controls are shown for comparison. Using a conservative Bonferroni α level analysis for all of the pairwise comparisons, given the sample sizes and variances of the patients and control groups, differences in mean T-cell numbers (B) were found between γcDef, ADADef, IL7RαDef, RAG1/2Def, CD3Def, AutoRec, and the normal control range (P < .015); differences in mean B-cell numbers (B) were found between ADADef (P = .001) and RAG1/2Def (P < .001) and the normal control range; differences in mean NK-cell numbers (B) were found between γcDef (P < .001), ADADef (P < .001), IL7RαDef (P = .002), RAG1/2Def (P < .001), AutoRec (P = .001), and the normal control values.