PBMC function before and after BMT in SCID patients. [³H]Thymidine incorporation by proliferating lymphocytes in response to PHA, ConA, and PWM was evaluated before (A; N = 151) and at latest time studied after transplantation (B; N = 120). Values are mean responses in counts per minute (cpm; ± SEM). Using a conservative Bonferroni α level analysis for all of the pairwise comparisons, given the sample sizes and variances of the patients and control groups at the latest transplantation date (B), the proliferative response to PHA of γcDef, ADADef, RAG1/2Def SCIDs was different (P < .015) from that of normal controls. Mean proliferation to ConA stimulus was different from normal controls only for ADADef (P = .005), and for the response to PWM only the IL-7RαDef was different from normal control values (P < .001).