Platelet functional response phenotype in the platelet function cohort. Platelet response to ADP and CRP-XL was measured by flow cytometry in the 500 subjects in the platelet function cohort. Data are shown as the standardized residuals of logit transformed data, after adjustment for confounding variables, as described by Jones et al.8 Fibrinogen binding in response to CRP-XL (FC) is shown on the x-axis, with P-selectin expression in response to CRP-XL (PC) on the y-axis. P-selectin expression in response to ADP (PA) is shown on the z-axis, and fibrinogen binding in response to ADP (FA) is shown by color gradient from red (low response) to green (high response). Correlations (r2 values) are given for the linear models, comparing all 4 variables P < .00001 in all cases).
