Associations and LD structure for PEAR1. (A) Association of the 14 SNPs in the PEAR1 locus on chromosome 1q23.1, for each of the 4 functional platelet responses (reading from the top: PA, PC, FA, and FC). Arrows indicate the SNPs with the highest association in each analysis. The correlative triangles indicate the strength of LD between SNPs, as estimated from HapMap data. The colors vary from white (disequilibrium coefficient < 1; logarithm of the odds [LOD] score < 2) to blue (disequilibrium coefficient = 1; LOD score < 2) to pink (disequilibrium coefficient < 1; LOD score ≥ 2) to bright red (disequilibrium coefficient = 1; LOD score ≥ 2). The chromosomal position (in Mb) is based on National Center for Biotechnology Information (NCBI) and build 36 coordinates, showing Ensembl (version 49) gene structure. (B) Twenty-six donors recalled on the basis of combined genotype for rs3737224 and rs41299597 showed an increase in the expression of PEAR1 protein on the surface of platelets stimulated with both 1 μg/mL CRP-XL and 10⁻⁵ M TRAP. This increase was larger in subjects carrying the minor allele for both SNPs (P = .001). Data are shown as the mean and 75 and 95% ranges for each genotype.