Schematic overview of the functional relationship between candidate gene products in platelets. Nodes that are colored represent genes in which sequence variation correlates with platelet functional. Genes that are colored gray have been tested, but no significant association was seen. Genes depicted as unfilled nodes were not tested but are included for pathway clarification. The diameter of a colored node is inversely proportional to the log base 10 of the lowest P value associated with any one of the platelet functional quantitative traits for that gene—the larger the node, the greater the effect (PC, P-selectin expression upon CRP-XL stimulation; FC, fibrinogen binding upon CRP-XL stimulation; PA, P-selectin expression upon ADP stimulation; FA, fibrinogen binding upon ADP stimulation). Sequence variation in a gene may be associated with more than one functional index (see Figure 4, Table 1, and supplemental Table 1 for a more detailed breakdown of individual effects). An edge between nodes denotes a functional relationship between gene products, and all are based on published data that have been interpreted by an expert in platelet signaling (J.-W.A.).