Schematic of CD56^bright and CD56^dim NK-cell cytokine and chemokine production upon target cell recognition and proinflammatory cytokine stimulation. Upon target cell recognition, CD56^dim NK cells produce increased levels of cytokines and chemokines compared with CD56^bright NK cells. In contrast, CD56^bright NK cells are the major cytokine producers when stimulated by proinflammatory cytokines (eg, IL-12, IL-15, and IL-18) or combinations thereof. Larger dots denote cytokine secretions, and smaller dots denote chemokine secretions.