Palmitoylation and prenylation are each essential for NRAS leukemogenesis in vivo. (A) Kaplan-Meier plot of cumulative survival of recipient mice transplanted with BM cells infected by NRASD12, NRASD12^C181S, or NRASD12^C186S containing retroviruses, or the MiG vector. (B) FACS analysis of GFP⁺ cells in peripheral blood of NRASD12, NRASD12^C181S, NRASD12^C186S, or GFP vector bone marrow transduction and transplantation mice.