Cumulative incidence of acute GVHD grades II through IV after HSCT according to the recipient HPSE gene SNPs rs4693608 and rs4364254 combinations. AA-TT and AA-TC genotype combinations were included in group HR; AG-TC and AG-TT genotype combinations were included in group MR; and GG-CC, GG-TC, GG-TT, and AG-CC genotype combinations were included in group LR. The incidence was higher in group HR compared with the MR and LR groups (P < .001).