Figure 1
Figure 1. Comparison of the DNA sequences at the direct MALT1-JH and reciprocal DH-MALT1 breakpoint junctions and the IGH and MALT1 germline. The IGH-MALT1 fusion products of the cases 1 and 2 are aligned with germline sequences of IGH (GenBank accession no. X97051.1) and MALT1 (GenBank accession no. AC104971). Nucleotide homologies to the germline are represented by vertical lines and mismatches by dots. De novo nucleotide additions are underlined. Solid boxes indicate RSS heptamers in the JH and DH segment germlines and a cryptic RSS heptamer and nonamer in the MALT1 germline. Dashed line boxes in case 2 indicate the 6-bp microhomologous sequence flanking the translocation breakpoint.

Comparison of the DNA sequences at the direct MALT1-JH and reciprocal DH-MALT1 breakpoint junctions and the IGH and MALT1 germline. The IGH-MALT1 fusion products of the cases 1 and 2 are aligned with germline sequences of IGH (GenBank accession no. X97051.1) and MALT1 (GenBank accession no. AC104971). Nucleotide homologies to the germline are represented by vertical lines and mismatches by dots. De novo nucleotide additions are underlined. Solid boxes indicate RSS heptamers in the JH and DH segment germlines and a cryptic RSS heptamer and nonamer in the MALT1 germline. Dashed line boxes in case 2 indicate the 6-bp microhomologous sequence flanking the translocation breakpoint.

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