Characterization of the pathologic parameters for all investigated mice. (A) Charts of spleen weight, blasts in BM, WBC (white blood cell counts), platelets, monocytes, and neutrophils are shown. Values for recipients of PIDE- and MLL·AF4 (MA)–transduced LSPCs are located in the average range. In contrast, recipients of AF4·MLL (AM)– and co(MA/AM)-transduced LSPCs developed typical signs of leukemia, with splenomegaly, increased WBC, monocytes, and neutrophils, reduced platelets, and infiltration of the BM with leukemic blasts. (B) Table summarizing all leukemic characteristics.