Detection of circulating MKs or their fragments by immunofluorescence labeling of blood smears from VWD2B using a MoAb specific for the αIIbβ3 complex. (A-E) Results for P2 with the R1306W VWD2B mutation show enlarged platelets confirming size diversity with occasional MK staining both with DAPI and for αIIbβ3. Control platelets are shown for comparison (F).