ADAP^−/− mice exhibit abnormal thrombus formation in vivo. (A) Representative carotid artery blood flow tracings from ADAP^+/+ and ADAP^−/− mice. A filter paper impregnated with 3.75% FeCl₃ was applied for 3 minutes (▼), and blood flow was monitored for an additional 25 minutes. (B) The average time to first occlusion was determined for each mouse, and results are shown as the average ± SEM of at least 7 mice per strain. *P < .01. (C) Hematoxylin and eosin–stained sections through the carotid artery excised 30 minutes after application of FeCl₃ (ADAP^+/+, left; ADAP^−/−, middle) or buffer (ADAP^+/+, right).