Hematologic analysis of the transgenic mice affected with B lymphoma. (A) EGFP expression in peripheral blood of a transgenic mouse affected with typical hematologic abnormalities at the indicated ages. (B) Spleens of 20-month-old wild-type and transgenic mice. (C-D) Morphologic appearance of spleen and peripheral blood cells (May-Gruenwald-Giemsa staining 63×/1.4 NA oil objective; C) and flow cytometric analysis of bone marrow and spleen cells (D) of transgenic mice exhibiting remarkable expansion of EGFP⁺ cells. Bars represent 10 μm in panel C.