Apc^min mice have normal hematopoiesis at steady state. (A) Full blood count examination at 4, 8, and 12 weeks. (B) Peripheral blood morphology demonstrating lymphocytes (top) and neutrophils (bottom). (C) LKS⁺ (lineage^lowcKit^highSca-1⁺ enriched for hematopoietic stem cells) numbers as a percentage of total bone marrow cells. (D) GMP numbers. (E) CMP numbers. (F) MEP numbers. (G) Hematopoietic stem and progenitor cell numbers expressed as a percentage of LKS⁺ cells. Multipotent progenitors (MPP) LKS⁺CD34⁺Flk2⁺, short-term hematopoietic stem cells (ST-HSC) LKS⁺CD34⁺Flk2⁻, and long-term HSC (LT-HSC) LKS⁺CD34⁻Flk2⁻. (H) Long-term HSC, CD150⁺CD48⁻LKS⁺ expressed as a percentage of LKS⁺ cells. (I) Colony-forming ability of 10⁴ bone marrow cells in cytokine-enriched methylcellulose (M3434; StemCell Technologies) and scored for colony (> 50 cells) number and morphology after 7 days. Megakaryocyte colonies (CFU-Mk), megakaryocyte-erythroid colonies (CFU-EMk), mixed multilineage colonies (CFU-GEMM), granulocyte-monocyte colonies (CFU-GM), and blast forming units-erythroid colonies (BFU-E). A total of n = 3 is shown for each condition.