Hemodynamic parameters of WT and PAI^−/− mice. The central arterial blood pressures and heart rates in 12- and 48-week-old WT and PAI-1^−/− mice were monitored continuously for at least 3 days by radiotelemetry. The means of systolic pressure (A), diastolic pressure (B), and pulse pressure (C) were then calculated. Heart rates (D) were also monitored in each individual WT and PAI-1^−/− mouse. The data represent means of at least 4 mice per group.