Histologic analysis reveals evidence of leukemia/lymphoma in GFP-Bfl-1ΔC/p53DD mice. (A top and middle) Spleen and liver sections from representative GFP-Bfl-1ΔC/p53DD or p53DD mice stained with hematoxylin and eosin. (Bottom) Peripheral blood smears from GFP-Bfl-1ΔC/p53DD or p53DD control mice stained with Wright-Giemsa. (B) Splenic cells recovered from diseased mice express GFP-Bfl-1ΔC or GFP-Bcl-xL along with p53DD as seen by Western blot, whereas those from healthy mice do not. The blot was probed with anti-GFP (top) or anti-p53 (bottom). HeLa cells transiently transfected with GFP-Bfl-1 or GFP-Bfl-1ΔC were used as controls.