Model of fibrinolytic and proteolytic cross-talk. In inflammatory processes of the vascular wall, activation of coagulation leads to fibrin deposits. Within this setting and according to data presented here, the fibrinolytic cross-talk mechanism could be an intermediary pathway for fibrinolysis and pericellular proteolysis. Fibrinolytic effects (top): plasminogen (Pg) bound to fibrin or to platelets could be activated by either monocyte- or MP-borne uPA (EMP or monocyte-derived microparticle [MoMP]). In ECM remodeling in the vascular wall (bottom), plasminogen bound to matrix components could be activated by MP-borne uPA (EMP or MoMP) or by macrophage-borne uPA.