Temporally increased plasma SIV viremia in CD8⁺ and CD20⁺ lymphocyte-depleted SIV-infected AGMs. SIV_sab9315BR RNA copy numbers were determined by quantitative PCR in control Ab-treated AGMs (A) and CD8⁺ and CD20⁺ lymphocyte-depleted AGMs (B). Median viral RNA copy number for both groups (C). *Statistically significant difference between the control (solid line, ●) and CD8⁺ and CD20⁺ lymphocyte-depleted group (dashed line, □) at the indicated time points (Mann-Whitney test, P ≤ .05). p.i. indicates postinfection.