Delayed appearance of SIV-specific humoral immune responses has no effect on set-point viremia of SIV-infected AGMs. SIV_sab9315BR NAb titers in control Ab-treated AGMs (A) and CD8⁺ and CD20⁺ lymphocyte-depleted AGMs (B). The median NAb titer was calculated for both groups (C). *Statistically significant difference between the control (solid line, ●) and CD8⁺ and CD20⁺ lymphocyte-depleted group (dashed line, □) at the indicated time points (Mann-Whitney test, P ≤ .05). The 2 animals with the most efficient/longest B-cell depletion, no. 365 (D) and no. 366 (E), in the group of antibody-treated and SIV-infected sabaeus AGMs are shown. The appearance of NAbs (red lines) coincided with the reappearance of peripheral blood B cells (blue lines) but had no effect on set-point viremia. p.i. indicates postinfection.