Treatment flowchart for IVE/MTX. *CHOP indicates cyclophosphamide (750 mg/m2, intravenously, day 1), doxorubicin (50 mg/m2, intravenously, day 1), vincristine (1.5 mg/m2; maximum of 2 mg/m2, intravenously, day 1), and prednisone (40 mg/m2, orally, days 1-5). **IVE indicates ifosfamide (3000 mg/m2, intravenously, days 1-3), epirubicin (50 mg/m2, intravenously, day 1), and etoposide (200 mg/m2, intravenously, days 1-3). ***Intermediate-dose methotrexate (1500 mg/m2, intravenously, day 1).