Pharmacokinetics of rFIXFc in cynomolgus monkeys. Monkeys were administered a single dose (0.5, 2, and 10 mg/kg body weight, corresponding to approximately 25, 100, or 500 IU/kg body weight) of rFIXFc (n = 2, 3, and 3, respectively). Blood samples were collected at 0.25, 0.5, 1, 8, 24, 48, 72, 96, 120, 144, and 168 hours after dosing, and plasma was prepared for analysis of protein concentration by FIXFc-specific ELISA.