Figure 1
![Figure 1. Cdc42−/− mice display mild thrombocytopenia. (A) Western blot analysis of Cdc42 expression in wild-type and Cdc42−/− platelets. GPIIIa expression was used as loading control. (B) Peripheral platelet counts (n = 6 per group). Error bars: wt, 860.95 ± 176.94; Cdc42−/−, 489.41 ± 128.91 (×103)/μL; ***P < .001. (C) Representative TEM pictures from wild-type and Cdc42−/− platelets. Scale bar equals 2 μm. (D) Cdc42−/− platelets are increased in size. Mean platelet width of wild-type and Cdc42−/− platelets (n = 25 per group). Error bars: wt, 0.64 ± 0.14; Cdc42−/−, 0.85 ± 0.21 [μm]; ***P < .001.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/115/16/10.1182_blood-2009-09-242271/4/zh89991050980001.jpeg?Expires=1735534092&Signature=tPbFuJG4zKWk2c4faAUX0TGu~txHGOKnR7~X6PHYX5uc1e~ozdwIr9gUvgOgr8YTPUseg854cGCsZyQGt8qfaJpnMzXVpyO2O3VD9NDwL1R4i2VFOvxrPtMIAPoJHw-PlTyDzsmrca1JrWfShJknQ6qses06peTdUkfE3wU~bO8blw2v2e9hqotVF-BpAXFBwaojpf-xmNCzL2-wqT6HgQU851zqAVc8OpMeqCDKUbwFOTVh4fB501cUjAxdagcGyMaLypr5hfayi6qjW6BhtHGrspaoC3dg7I5wsoGmIjqot~JaKMg2CRydwO01O90SX6DKx2MbF15dprCs1vPqCA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Cdc42−/− mice display mild thrombocytopenia. (A) Western blot analysis of Cdc42 expression in wild-type and Cdc42−/− platelets. GPIIIa expression was used as loading control. (B) Peripheral platelet counts (n = 6 per group). Error bars: wt, 860.95 ± 176.94; Cdc42−/−, 489.41 ± 128.91 (×103)/μL; ***P < .001. (C) Representative TEM pictures from wild-type and Cdc42−/− platelets. Scale bar equals 2 μm. (D) Cdc42−/− platelets are increased in size. Mean platelet width of wild-type and Cdc42−/− platelets (n = 25 per group). Error bars: wt, 0.64 ± 0.14; Cdc42−/−, 0.85 ± 0.21 [μm]; ***P < .001.
