Figure 2
Schematic of the mouse Runx1 locus and the mutations introduced in the distal P1 and proximal P2 promoter region to generate the P1N (see supplemental Figure 1) and P2neo27 alleles, respectively. Neo indicates neomycin resistance gene. Runx1 coding exons (black boxes) with their untranslated regions (gray boxes) are numbered as in Levanon et al17 and Bee et al.20 Exons coding for the DNA-binding runt domain are indicated. The position of the hematopoietic +23 enhancer is indicated by an arrow.
