Figure 1
Figure 1. Tmprss6−/− and >Tmprss6+/− mice show abnormal systemic iron homeostasis. (A) Hepatic hepcidin (Hamp) mRNA expression relative to β-actin (Actb) mRNA expression in Tmprss6+/+, Tmprss6+/−, and Tmprss6−/− mice. (B) Nonheme liver iron concentrations (μg/g wet weight) of Tmprss6+/+, Tmprss6+/−, and Tmprss6−/− mice. (C) Hepatic Bmp6 mRNA expression relative to β-actin mRNA expression in Tmprss6+/+, Tmprss6+/−, and Tmprss6−/− mice. (D) Hepatic Id1 mRNA expression relative to β-actin mRNA expression in Tmprss6+/+, Tmprss6+/−, and Tmprss6−/− mice. Mean values from analysis of 8-week-old female mice (6-8 mice per genotype) are graphed. In panels A, C, and D, mRNA expression ratios are normalized to a Tmprss6+/+ mean value of 1. Error bars represent SEM. ‡P < .05, #P < .005, §P < .001, and *P value not significant, compared with Tmprss6+/+ mice. †P < .001, ¶P value not significant, compared with Tmprss6+/− mice.

Tmprss6−/− and >Tmprss6+/− mice show abnormal systemic iron homeostasis. (A) Hepatic hepcidin (Hamp) mRNA expression relative to β-actin (Actb) mRNA expression in Tmprss6+/+, Tmprss6+/−, and Tmprss6−/− mice. (B) Nonheme liver iron concentrations (μg/g wet weight) of Tmprss6+/+, Tmprss6+/−, and Tmprss6−/− mice. (C) Hepatic Bmp6 mRNA expression relative to β-actin mRNA expression in Tmprss6+/+, Tmprss6+/−, and Tmprss6−/− mice. (D) Hepatic Id1 mRNA expression relative to β-actin mRNA expression in Tmprss6+/+, Tmprss6+/−, and Tmprss6−/− mice. Mean values from analysis of 8-week-old female mice (6-8 mice per genotype) are graphed. In panels A, C, and D, mRNA expression ratios are normalized to a Tmprss6+/+ mean value of 1. Error bars represent SEM. ‡P < .05, #P < .005, §P < .001, and *P value not significant, compared with Tmprss6+/+ mice. †P < .001, ¶P value not significant, compared with Tmprss6+/− mice.

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