Wiskostatin inhibits chemokine-induced integrin-dependent NK-cell migration. NK cells were preincubated for 1 hour with different concentration of Wiskostatin or vehicle (DMSO) and then assayed for their ability to migrate through ICAM-1 (5 μg/mL)–precoated polycarbonate filters using CXCL12/SDF1 (10nM) or CX3CL1/fractalkine (1nM) as chemoattractants. Data are expressed as the mean ± SD of the percentage of migrated cells obtained from 3 independent determinations. Statistical significance was evaluated by Student t test, *P < .02.