Model for CLEC-2 signaling. Our observations support the following model: (1) CLEC-2 translocates to lipid rafts independently of Src kinases, actin polymerization and release of ADP and TxA₂; (2) Src kinase phosphorylation of CLEC-2 occurs in lipids rafts; (3) CLEC-2 tyrosine phosphorylation is dependent on actin polymerization; (4) tyrosine phosphorylation of CLEC-2 and downstream signaling events are reinforced by generation of the second mediators ADP and TxA₂, which in turn activate Rac.