Switch from TG to MP. A total of 2027 eligible children were randomized to TG (1017) or MP (1010) and are included in this intent-to-treat analysis. The first 414 subjects randomized to TG began consolidation with TG at 60 mg/m²; the last 603 began at 50 mg/m². During the course of treatment, 581 patients switched from TG to MP. Of the 1017 subjects, 436 (43%) received TG throughout treatment: 294 in cohort 1 and 142 in cohort 2.