Engulfment of platelets by monocytes/macrophages. Blood smears were prepared from dengue virus–infected rhesus monkeys and Wright Giemsa and immunofluorescence stainings were performed. Images were acquired on a Zeiss AxioImager A1 epifluorescence microscope with an AxioCam MRC5 camera. Images were captured with a Zeiss 100×/1.3 Plan Neofluar oil objective lens and then processed with AxioVision Release 4.5 software. (A-B) Wright Giemsa staining revealed that tangled platelets were engulfed by monocytes. (C) Immunofluorescence staining revealed that some of these platelets were positive for dengue viral antigen (3H5, red). Nuclear was stained with DAPI (blue) and SYTOX Green.