Figure 1
Control SCID mice recover from radiation-induced thrombocytopenia. Platelet counts in control irradiated SCID mice transferred with either nothing (□; n = 9) or 5 × 104 splenocytes from BALB/c mice immunized against third-party antigenic platelets from C57BL/6 mice (○; n = 15). Thrombocytopenia at day 7 occurred in all mice irradiated (asialo GM-1 treatment had no effect on platelet counts). The data are expressed as platelet counts (× 109/L) ± SEM over time (days). The solid horizontal line represents the normal mean platelet count ± SEM (hatched lines) from 149 healthy SCID mice. The star refers to statistical significance (P < .001) between the observed platelet count for all control mice and the normal mean platelet count.
