Population structure of gene-corrected cells. (A) The number of infused cells per kilogram in each patient is shown on the x-axis. The number of unique integration sites detected at each time point is shown on the y-axis. For the comparison, only data obtained by cleaving the genome with MseI were used because this allowed a fair comparison among samples (complete data are summarized in supplemental Table 1). (B) The longitudinal trends in diversity are shown. The x-axis shows time after infusion of gene-corrected cells, and the y-axis shows diversity as quantified using the Shannon Diversity Index. Time points corresponding to the adverse events in patients no. 7 and no. 10 are marked.