AID expression levels and high CSR segregate patients with UM CLL into 3 subgroups with different clinical progression. (A-B) Significant differences in P values in mRNA AID expression (A) and percentage of CLL B cells with clonally related CSR (B) allow us to segregate patients with UM disease into 3 different groups: subgroup I (6 patients) identified as AID^+/+ and high clonal CSR (≥ 5%), subgroup II (7 patients) identified as AID⁺ and low clonal CSR, and subgroup III (5 patients) identified as AID^neg without clonal CSR. Significant P values are shown (*) (P ≤ .001, Mann-Whitney test). (C-D) Correlations of AID expression and PFS (C) and clonal CSR and PFS (D) for the 3 subgroups are plotted. Both analyses indicate a significant negative correlation; P ≤ .001 considered significant (*) by Spearman rank test. P < .001 (Spearman rank coefficient ρ = −0.77) for AID expression correlated to PFS and P < .001 (Spearman rank coefficient ρ = −0.80) for clonal CSR linked to PFS.