Kaplan-Meier curves based on AID and CSR expression in the 3 subgroups in patients with UM CLL comparing the PFS and OS. The Kaplan-Meier method was used to construct survival curves for PFS (A) and OS (B), and results were compared with the log-rank test Spearman. P values refer to the log-rank test. Subgroup I corresponds to UM CLL AID^+/+ and CSR ≥ 5%; subgroup II to UM CLLs AID⁺ and low clonally related CSR, and subgroup III to UM CLL AID^neg and CSR not related to the tumoral clone.