EBV viral load and EBV-specific humoral response in ChAglyCD3- and placebo-treated patients. Mean (± SEM) titers expressed as OD indexes of VCA IgG, VCA IgM, and EA IgG are shown for patients treated with ChAGlyCD3 (▴) or placebo (□). Black dotted lines represent the cut-off value for positive detection. Mean (± SEM) EBV copy numbers expressed as log/μg DNA are also shown for the 2 groups of patients. The threshold of 1.5 log EBV copies/μg DNA (mean value found in all patients at baseline ± 3 SD) is represented by a dotted line. *P < .05; **P < .001.