Profile of cellular cytokine levels after inhibition of PI3K/Akt/mTOR pathway members. IL-6 (A), IL-10 (B), IP-10 (C), HGF (D), MIG (E), and VEGF (F) levels on treatment with indicated compounds or with vehicle control. Changes in cytokine levels are represented as percentage change from vehicle-treated levels, which were set to 100%. Error bars represent SD. The PI3K/mTOR dual inhibitor NVP-BEZ235 dramatically reduces levels of the indicated cytokines secreted into the growth medium. P < .001 by Tukey post-hoc test.