Skin biopsy demonstrating the presence of tissue macrophages and plasma cells, despite the virtual absence of circulating monocytes and B cells. Full-thickness skin biopsy from patient 1.II.1 demonstrating granulomatous inflammation within the dermis (left). Immunohistochemistry reveals the presence of macrophages, stained with monoclonal antibody to KP-1/CD68 (center). Plasmacytosis is also seen in the tissue (hematoxylin and eosin stain; right). Images were taken using an Olympus Bx41 microscope, objectives UPlanFI 40×/0.75 ∞/0.17, and UPlanFI 20×/05.0 ∞/0.17, with an adaptor U-TV0.5×C using a digital camera Q-imaging Micropublisher 5.0RTV. The images were captured using Q-Capture Version 3.1 and imported into Adobe Photoshop 7.0.