Altered cell function and signal pathways in patients as assessed by microarray analysis of PMN transcripts. Ten most significant BioFunctions were identified using Ingenuity Pathways Analysis (Ingenuity Systems; www.ingenuity.com). Data are based on PMN transcripts differentially expressed in the patients compared with healthy control subjects. The P value indicates the likelihood that association of the specific set of transcripts and the indicated process or pathway is the result of random chance. B-H P value indicates P values after Benjamini-Hochberg correction for multiple comparisons.