Genomic instability (based on microsatellite analysis) in oral and nasal mucosa. (Top) Percent of subjects with genomic instability detected in oral and nasal specimens among the following subjects: Healthy individuals, Chemotherapy-only controls (received chemotherapy but no transplantation), Autologous HCT controls, Short-term survivors of allogeneic HCT (7-98 days), and Long-term survivors of allogeneic HCT (4-22 years). (Bottom) Number of microsatellite markers showing instability in long-term allogeneic HCT survivors with and without history of oral cGVHD. Black horizontal lines represent the median number of microsatellite markers showing instability. Significance of difference calculated for the 2 groups was P = .007 in univariate analysis (Mann-Whitney-Wilcoxon rank sum test) and P = .005 in multivariate analysis (multinomial logistic regression).