Figure 1
![Figure 1. Glycan epitopes and monosaccharide analogs. (A) Putative structure of selectin-binding glycan located at the N-terminus of PSGL-1. This glycan has a terminal tetrasaccharide sLeX epitope and binding sites for DSA and AAL lectins. Neuraminidase cleaves sialic acid (NeuAc) residues to expose the terminal trisaccharide Lewis-X (LeX) epitope. Metabolic inhibition of these glycan structures may reduce leukocyte selectin-binding function. (B) Structure of per-acetylated compounds GalNAc, 4F-GalNAc, 4F-GlcNAc, and [14C]4F-GalNAc.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/115/6/10.1182_blood-2009-07-231480/4/zh89990948290001.jpeg?Expires=1735513561&Signature=ceHGhcB~HJDcK~NT65uWze~uoOB2TWShlT6hB07rjA0YWGV4LXMYpPdVKG7fdMqK835fesOfLNHhFFVogo4ZDNs92y9ccwUoG-Ws~ADZIDyUC2xa1qDG3yKejeNgpGw-rxX1Kx450s2rvYnp7vqXbph202yA-UEfADmvl1qVccgkEPhp0OxSL13AYX44DLwIdZ-BQ1CTLEoV6CI9okdEXqR9OqyA~VdtL-U9keAgYEq-vqkg3JlL-SjYKia-Q2zVIzpmjFRSOqhNukZ1o0YxNNhpnOCJKv0vppNXgZGk~2QFiNquwU~e6ua306W9eUV1yzf~2CG98eam4XwAecZWeA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Glycan epitopes and monosaccharide analogs. (A) Putative structure of selectin-binding glycan located at the N-terminus of PSGL-1. This glycan has a terminal tetrasaccharide sLeX epitope and binding sites for DSA and AAL lectins. Neuraminidase cleaves sialic acid (NeuAc) residues to expose the terminal trisaccharide Lewis-X (LeX) epitope. Metabolic inhibition of these glycan structures may reduce leukocyte selectin-binding function. (B) Structure of per-acetylated compounds GalNAc, 4F-GalNAc, 4F-GlcNAc, and [14C]4F-GalNAc.
