Figure 2
Figure 2. Chemical structure of GMI-1070. GMI-1070 is a glycomimetic pan-selectin inhibitor that was rationally designed on the basis of the bioactive conformation of sLex in the binding site of E-selectin as determined empirically by nuclear magnetic resonance methods. Incorporation of a sulfate-binding domain is important for interactions with P- and L-selectins.

Chemical structure of GMI-1070. GMI-1070 is a glycomimetic pan-selectin inhibitor that was rationally designed on the basis of the bioactive conformation of sLex in the binding site of E-selectin as determined empirically by nuclear magnetic resonance methods. Incorporation of a sulfate-binding domain is important for interactions with P- and L-selectins.

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