Immunological monitoring of ^p190BCR-ABL–specific memory T-cell responses in the BM from 10 Ph⁺ ALL patients on IM alone and correlation with the disease course. Longitudinal data tracking MRD kinetics (right, y-axis; red) and IFN-γ–ELISPOT responses (left, y-axis, blue) are summarized in a single time-course graph for each patient. On each patient's graph, representative memory BM T-cell profiles are also depicted over the related time points (indicated by asterisks). T-cell memory subsets were defined as following: CD62L⁻CD45RA⁻ (EM, dark blue), CD62L⁻CD45RA⁺ (EMRA, light blue), CD62L⁺CD45RA⁻ (CM, yellow), CD62L⁺CD45RA⁺ (naive T cells, white). Data for each subset are expressed as relative percentages on the total of either CD8⁺ or CD4⁺ T cells.