Expression of selected myeloma survival kinases in primary multiple myeloma versus an atlas of nonhematopoietic human tissues. Histograms show the differential patterns of expression of myeloma survival kinases (GRK6, HK1, and FGFR3) and of control genes (CD138 and β-actin) in primary human somatic tissues (103 arrays), primary multiple myeloma tumor cells (115 arrays), and in early stage plasma cell disorders: monoclonal gammopathy of uncertain significant (MGUS) and smoldering multiple myeloma (SMM; data from SymAtlas, Novartis Research Foundation and from Mayo Clinic; GEO accession no. GSE 6477). Array-based gene expression data were normalized per chip (sample) to the median signal intensity of expressed genes (genes with present detection call and/or MAS5 signal intensity > 200); a value of 1.0 thus represents the median expression intensity of genes whose expression can be reliably detected within each sample type.