Role of AMPKα2 in clot retraction and thrombus stability. (A) Expression of AMPKα subunits in murine platelets from wild-type (α1^+/+, α2^+/+), AMPKα1^−/−, and AMPKα2^−/− mice, including (B) thrombin-induced clot retraction in platelet-rich plasma from the same animals. (C) Representative images and summary of FeCl₃-induced thrombus formation in carotid arteries from AMPKα2^+/+ and AMPKα2^−/− mice. The arrows indicate emboli detaching from the thrombus. The graphs summarize data for 8 animals from each group; ^###P < .001 vs AMPKα2^+/+.