Figure 5
![Figure 5. Role of AMPKα2 in the phosphorylation of β3 integrin. (A) Effect of AMPK inhibition (compound C [Comp C], 10μM) on the thrombin-induced phosphorylation (p-Tyr747) of β3 integrin in washed human platelets. (B) Thrombin-induced phosphorylation of β3 integrin in platelets from AMPKα2+/+, α2−/−, α1+/+, and α1−/− mice. The bar graphs summarize data from 6 different experiments; *P < .05 and **P < .01 vs solvent (Sol)–treated platelets.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/116/12/10.1182_blood-2010-04-279612/4/zh89991057640005.jpeg?Expires=1735829464&Signature=VdY9~Q1m8irDLxaH770HBlPD2wbDTx2-~E89TXR99nzvD9fhUz4EmD1rgmo7mgu3w4Ui0LYnvLHRPzeWfNw-EfE89fnR96OCOtGrBDN5mNbnP1uISoGq7sxhiQTpXjNrXgKtBMMdwX--f338UfCiEzPKCGHccOCsaMO1pTnjgLH5feE9fbjc85l2vhxuVDqitANAsnL-JxijDsKysNzwrFOK27gKlZRT7sM4qlloSiWFGFRWWsYSspeAS~wmOE-Hk18FIq2IZiaLaKS84tPGLypuzpHQESe1J66oOAndJSBKfDLWXIei8zgfVEBro3gk~gAWKcUM91xIwVwkNARkkQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Role of AMPKα2 in the phosphorylation of β3 integrin. (A) Effect of AMPK inhibition (compound C [Comp C], 10μM) on the thrombin-induced phosphorylation (p-Tyr747) of β3 integrin in washed human platelets. (B) Thrombin-induced phosphorylation of β3 integrin in platelets from AMPKα2+/+, α2−/−, α1+/+, and α1−/− mice. The bar graphs summarize data from 6 different experiments; *P < .05 and **P < .01 vs solvent (Sol)–treated platelets.
