Localized extravascular chemokine release results in decreased crawling distance and crawling velocity. (A) Actual crawling distance and (B) calculated crawling velocity of neutrophils in response to MIP-2 superfusion (n = 32, 4 mice) or MIP-2–containing gel (n = 57, 5 mice). *P < .05 vs WT activated by MIP-2 superfusion.