Tmod1-null RBC shapes are heterogeneous with rounded elliptocytes, spherocytes, and microcytes, resembling spherocytic elliptocytosis. (A) Peripheral blood smears from Tmod1^−/−Tg+ mice show significant populations of rounded elliptocytes (arrowheads), as well as spherocytes and a few microcytes (arrows). (B) Scanning electron microscopy (SEM) of RBCs from a Tmod1^+/+Tg+ mouse and a Tmod1^−/−Tg+ mouse show reduction of the central biconcavity as well as oval-shaped, spherical, and some smaller cells in the absence of Tmod1. Bars, 10 μm.