Mutations discovered by massive parallel sequencing of 102 MCL cases. (A) Total numbers of nonsynonymous mutations confirmed in 13 target genes analyzed. Next to the well-known and previously described mutations in ATM, TP53, and NOTCH1, UBR5 has the highest percentage of deleterious mutations including 7 splice-site affecting mutations. (B) The schematic represents the status of the 5 most recurrently mutated genes (rows) in MCL in 102 patients (columns) analyzed (red: splice site mutation; dark blue: indel; light blue: nonsense mutation; gray: missense mutation; and white: wild type. Asterisks highlight mutations validated as being somatic by Sanger sequencing.