Liver transduction of hexon modified Ad5 vectors using 1 × 10¹¹ vp per mouse. β-galactosidase transgene expression of Ad5 and hexon modified adenoviral vectors after high-dose administration of Ad to macrophage-depleted mice. Animals were killed 48 hours after injection and livers harvested for analysis. (*P < .0001 vs Ad5, n = 5).